Uric acid and inflammation in kidney disease

Uric acid and chronic kidney disease: which is chasing which?

Serum uric acid is commonly elevated in subjects with chronic kidney disease (CKD), but was historically viewed as an issue of limited interest. Recently, uric acid has been resurrected as a potential contributory risk factor in the development and progression of CKD. Most studies documented that an elevated serum uric acid level independently predicts the development of CKD. Raising the uric a...

Uric Acid in Chronic Kidney Disease: a Clinical Appraisal

A consistent body of evidence supports an independent association between uric acid (UA) level and the risk of chronic kidney disease (CKD) in humans. It has been observed in experimental data that UA is capable of inducing renal damage through several pathways, including activation of the renin-angiotensinaldosterone system (RAAS), oxidative stress, and inflammation. Treatment with urate lower...

Uric acid levels increase risk for new-onset kidney disease.

Serum uric acid, kidney volume and progression in autosomal-dominant polycystic kidney disease.

BACKGROUND Hyperuricemia has been implicated in the development and progression of chronic kidney disease, both in animal experiments and in clinical studies. As a potentially modifiable risk factor, we examined whether serum uric acid levels correlate with early hypertension, kidney volume and progression to end-stage renal disease (ESRD) in autosomal-dominant polycystic kidney disease (ADPKD)...

Uric acid, gout and the kidney.

Uric acid is 2,6,8-trihydroxypurine, and seems to be present in almost all organisms. In snakes, reptiles, birds and spiders it is the main end-product of all nitrogenous metabolism, and these groups of animals have kidneys which are capable of secreting large amounts of uric acid. This is then excreted as a slurry of crystals, which confers the advantage that the nitrogenous end-product can be...